Article
Genomically imposed and somatically modified human thymocyte V beta gene repertoires.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1991
Baccala R, Kono D H, Walker S, Balderas R S, Theofilopoulos A N
Abstract excerpt
The effect of thymic selection on the expressed human T-cell antigen receptor beta-chain variable region (V beta) gene repertoire was examined by using a multiprobe RNase protection assay. The relative abundance of transcripts for 22 V beta genes (encompassing 17 of the 20 human V beta gene subfamilies) within a thymus, and among 17 thymuses, was variable. On the basis of the presence of corresponding mRNAs, no...
Topics
- Child
- Child, Preschool
- Female
- Genetic Variation
- Humans
- Infant
- Infant, Newborn
- Macromolecular Substances
- Male
- RNA, Messenger
- Receptors, Antigen, T-Cell