Clonal expansion of T cells and HIV genotypes in microdissected splenic white pulps indicates viral replication in situ and infiltration of HIV-specific cytotoxic T lymphocytes.

doi:10.1007/978-1-4615-1995-9_15

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Article

Clonal expansion of T cells and HIV genotypes in microdissected splenic white pulps indicates viral replication in situ and infiltration of HIV-specific cytotoxic T lymphocytes.

Advances in experimental medicine and biology - 1 Jan 1995

Cheynier R, Henrichwark S, Hadida F, Pelletier E, Oksenhendler E, Autran B, Wain-Hobson S

Abstract excerpt

Human immunodeficiency virus (HIV) replication and T cell proliferation was investigated in situ by a PCR based analysis of individual microdissected splenic white pulps. Founder effects, revealed by an exquisite compartmentalization of HIV genotypes and T cells, indicated the recruitment of late...

Topics

Amino Acid Sequence
Antibody Specificity
Clone Cells
Dissection
Genotype
HIV
HIV Antibodies
Humans
Micromanipulation
Molecular Sequence Data
Spleen
T-Lymphocytes, Cytotoxic
Virus Replication

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Identifiers

PMID: 7572391
DOI: 10.1007/978-1-4615-1995-9_15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7572391-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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