Article
Analysis of the T-cell receptor beta-chain variable-region (V beta) repertoire in monozygotic twins discordant for human immunodeficiency virus: evidence for perturbations of specific V beta segments in CD4+ T cells of the virus-positive twins.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1994
Rebai N, Pantaleo G, Demarest J F, Ciurli C, Soudeyns H, Adelsberger J W, Vaccarezza M, Walker R E, Sekaly R P, Fauci A S
Abstract excerpt
We analyzed the T-cell receptor (TCR) V beta repertoire in human immunodeficiency virus type 1 (HIV-1)-infected individuals at different stages of disease. To circumvent the effect of HLA and other loci on the expressed TCR repertoire, we compared the TCR repertoire in nine pairs of monozygotic twins who were discordant for HIV infection. A semiquantitative polymerase chain reaction (PCR) assay and flow cytometry...
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