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Article

Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centers

19 Dec 2000

Abstract excerpt

The tremendous dynamics of HIV infection finds expression in the tempo of sequence diversification. Genetic diversity calculations require the clearance of a majority of infected cells, the obvious predator being anti-HIV immune responses. Indeed, infiltration of germinal centers (GCs) by HIV-specific CD8(+) cytotoxic T lymphocytes has been described. A corollary to this description would be limited diffusion of...

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PMID: 11121058
DOI: 10.1073/pnas.97.26.14566

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