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Article

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.

The Journal of experimental medicine - 1 Oct 1993

Jacob J, Przylepa J, Miller C, Kelsoe G

Abstract excerpt

In the murine spleen, germinal centers are the anatomic sites for antigen-driven hypermutation and selection of immunoglobulin (Ig) genes. To detail the kinetics of Ig mutation and selection, 178 VDJ sequences from 16 antigen-induced germinal centers were analyzed. Although germinal centers appeared by day 4, mutation was not observed in germinal center B cells until day 8 postimmunization; thereafter, point...

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Identifiers

PMID: 8376935
DOI: 10.1084/jem.178.4.1293
PMCID: PMC2191212

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Source receipt: pubmed, retrieved 7 Sept 2026.

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