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Article

Locus-specific somatic hypermutation in germinal centre T cells.

Nature - 8 Dec 1994

Zheng B, Xue W, Kelsoe G

Abstract excerpt

Somatic hypermutation and affinity-driven selection of active immunoglobulin genes occur in germinal centres (GCs), resulting in the generation of high-affinity memory B cells. In contrast, T lymphocytes do not require the germinal centre microenvironment to establish memory and the T-cell antigen receptor (TCR) genes, though homologous to immunoglobulin genes, are believed to be incapable of hypermutation. Here...

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PMID: 7990929
DOI: 10.1038/372556a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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