Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting and selection of mutations in human Vlambda rearrangements.

European journal of immunology - 1 Jun 2000

Monson N L, Dörner T, Lipsky P E

Abstract excerpt

The impact of somatic hypermutation on the lambda light chain repertoire of individual IgM+ peripheral B cells in the absence (nonproductive rearrangements) and presence (productive rearrangements) of selective influences was analyzed. In the 27 mutated nonproductive VlambdaJlambda, rearrangements obtained from individual peripheral B cells, a significantly greater mutational frequency was observed in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA, Complementary
Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Joining Region

Share to Immunoglobulin lambda-Chains

Share to Immunoglobulin Variable Region

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 10898495
DOI: 10.1002/1521-4141(200006)30:6<1597::AID-IMMU1597>3.0.CO;2-R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting and selection of mutations in human Vlambda rearrangements.PMID 10898495Read ↗

Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs.Semantic proximity Read ↗

Targeting and subsequent selection of somatic hypermutations in the human V kappa repertoire.Semantic proximity Read ↗

Delineation of selective influences shaping the mutated expressed human Ig heavy chain repertoire.Semantic proximity Read ↗

Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.Semantic proximity Read ↗

Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements.Semantic proximity Read ↗

Enhanced mutational activity and disturbed selection of mutations in V(H) gene rearrangements in a patient with systemic lupus erythematosus.Semantic proximity Read ↗

Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire.Semantic proximity Read ↗

Molecular Mechanisms and Selection Influence the Generation of the Human VλJλ RepertoireSemantic proximity Read ↗

Somatic hypermutation targeting to intrinsic hotspots of immunoglobulin genes in follicular lymphoma and multiple myeloma.Semantic proximity Read ↗

Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands.Semantic proximity Read ↗

Enhanced mutational activity of Vkappa gene rearrangements in systemic lupus erythematosus.Semantic proximity Read ↗

Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.