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Article

A role for FADD in T cell activation and development.

Immunity - 1 Apr 1998

Walsh C M, Wen B G, Chinnaiyan A M, O'Rourke K, Dixit V M, Hedrick S M

Abstract excerpt

FADD is a cytoplasmic adapter molecule that links the family of death receptors to the activation of caspases during apoptosis. We have produced transgenic mice expressing a dominantly interfering mutant of FADD, lacking the caspase-dimerizing death effector domain, as well as mice overexpressing the poxvirus serpin, CrmA, an inhibitor of caspases downstream of FADD. While thymocytes from either line of mice were...

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Source

Identifiers

PMID: 9586634
DOI: 10.1016/s1074-7613(00)80549-x

Genes

FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A role for FADD in T cell activation and development.PMID 9586634Read ↗

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Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.Semantic proximity Read ↗

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