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Article

A role for FADD in T cell activation and development.

Immunity - 1 Apr 1998

Walsh C M, Wen B G, Chinnaiyan A M, O'Rourke K, Dixit V M, Hedrick S M

Abstract excerpt

FADD is a cytoplasmic adapter molecule that links the family of death receptors to the activation of caspases during apoptosis. We have produced transgenic mice expressing a dominantly interfering mutant of FADD, lacking the caspase-dimerizing death effector domain, as well as mice overexpressing...

Topics

Adaptor Proteins, Signal Transducing
Animals
Apoptosis
Carrier Proteins
Cysteine Endopeptidases
Cysteine Proteinase Inhibitors
Fas-Associated Death Domain Protein
Humans
Lymphatic Diseases
Lymphocyte Activation
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Poxviridae

Serpins

T-Lymphocytes

Viral Proteins

Source

Identifiers

PMID: 9586634
DOI: 10.1016/s1074-7613(00)80549-x

Genes

FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9586634-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A role for FADD in T cell activation and development.PMID 9586634Read ↗

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.Semantic proximity Read ↗

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes.Semantic proximity Read ↗

p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice.Semantic proximity Read ↗

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis.Semantic proximity Read ↗

Constitutive phosphorylation mutation in Fas-associated death domain (FADD) results in early cell cycle defects.Semantic proximity Read ↗

Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice.Semantic proximity Read ↗

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.Semantic proximity Read ↗

The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity.Semantic proximity Read ↗

Structural requirements for signal-induced target binding of FADD determined by functional reconstitution of FADD deficiency.Semantic proximity Read ↗

A novel genotyping strategy based on allele-specific inverse PCR for rapid and reliable identification of conditional FADD knockout mice.Semantic proximity Read ↗

Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development.Semantic proximity Read ↗

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.Semantic proximity Read ↗

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