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Article

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2010

Osborn Stephanie L, Diehl Gretchen, Han Seong-Ji, Xue Ling, Kurd Nadia, Hsieh Kristina, Cado Dragana, Robey Ellen A, Winoto Astar

Abstract excerpt

Cell death is an important mechanism to limit uncontrolled T-cell expansion during immune responses. Given the role of death-receptor adapter protein Fas-associated death domain (FADD) in apoptosis, it is intriguing that T-cell receptor (TCR)-induced proliferation is blocked in FADD-defective T cells. Necroptosis is an alternate form of death that can be induced by death receptors and is linked to autophagy. It...

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Identifiers

PMID: 20615958
DOI: 10.1073/pnas.1005997107
PMCID: PMC2919948

Genes

FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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