Article
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency.
Nature - 26 Sept 2002
Chun Hyung J, Zheng Lixin, Ahmad Manzoor, Wang Jin, Speirs Christina K, Siegel Richard M, Dale Janet K, Puck Jennifer, Davis Joie, Hall Craig G, Skoda-Smith Suzanne, Atkinson T Prescott, Straus Stephen E, Lenardo Michael J
Abstract excerpt
Apoptosis is a form of programmed cell death that is controlled by aspartate-specific cysteine proteases called caspases. In the immune system, apoptosis counters the proliferation of lymphocytes to achieve a homeostatic balance, which allows potent responses to pathogens but avoids autoimmunity. The CD95 (Fas, Apo-1) receptor triggers lymphocyte apoptosis by recruiting Fas-associated death domain (FADD),...
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