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Article

Structural requirements for signal-induced target binding of FADD determined by functional reconstitution of FADD deficiency.

The Journal of biological chemistry - 9 Sept 2005

Imtiyaz Hongxia Z, Zhang Yuhang, Zhang Jianke

Abstract excerpt

FADD is a key adaptor modulating several signaling pathways such as apoptosis induced by Fas (CD95) and tumor necrosis factor receptor 1, and cell proliferation induced by mitogens. Whereas mutations in Fas disrupt its binding to FADD and cause autoimmune lymphoproliferative (lpr) syndromes, a FADD deficiency blocks embryonic development in mice. To delineate the multifunction of FADD in vivo, we performed...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fas-Associated Death Domain Protein

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Source

Identifiers

PMID: 16009710
DOI: 10.1074/jbc.M504138200

Genes

FADD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural requirements for signal-induced target binding of FADD determined by functional reconstitution of FADD deficiency.PMID 16009710Read ↗

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