Article
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
Science (New York, N.Y.) - 20 Mar 1998
Yeh W C, de la Pompa J L, McCurrach M E, Shu H B, Elia A J, Shahinian A, Ng M, Wakeham A, Khoo W, Mitchell K, El-Deiry W S, Lowe S W, Goeddel D V, Mak T W
Abstract excerpt
FADD (also known as Mort-1) is a signal transducer downstream of cell death receptor CD95 (also called Fas). CD95, tumor necrosis factor receptor type 1 (TNFR-1), and death receptor 3 (DR3) did not induce apoptosis in FADD-deficient embryonic fibroblasts, whereas DR4, oncogenes E1A and c-myc, and...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Apoptosis
- Carrier Proteins
- Cell Transformation, Neoplastic
- Cells, Cultured
- Doxorubicin
- Embryonic and Fetal Development
- Endothelium, Vascular
- Fas-Associated Death Domain Protein