Article
p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice.
Current biology : CB - 9 Apr 1998
Zörnig M, Hueber A O, Evan G
Abstract excerpt
Members of the tumour necrosis factor (TNF) receptor family exert pleiotropic effects and can trigger both apoptosis and proliferation [1]. In their cytoplasmic region, some of these receptors share a conserved sequence motif - the 'death domain' - which is required for transduction of the apopto...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Apoptosis
- Carrier Proteins
- Cell Division
- Cells, Cultured
- Fas-Associated Death Domain Protein
- Genes, Dominant
- Lymphocyte Activation
- Mice
- Mice, Transgenic
- Mitogens
- Mutation
- Receptors, Tumor Necrosis Factor
- T-Lymphocytes
- Thymus Gland
- Tumor Suppressor Protein p53
- fas Receptor