Article
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes.
The EMBO journal - 2 Feb 1998
Newton K, Harris A W, Bath M L, Smith K G, Strasser A
Abstract excerpt
Members of the tumour necrosis factor receptor family that contain a death domain have pleiotropic activities. They induce apoptosis via interaction with intracellular FADD/MORT1 and trigger cell growth or differentiation via TRADD and TRAF molecules. The impact of FADD/MORT1-transduced signals o...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Apoptosis
- Carrier Proteins
- Cell Division
- Cells, Cultured
- Clone Cells
- Fas-Associated Death Domain Protein
- Genes, Dominant
- Humans
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred MRL lpr
- Mice, Transgenic
- Mitogens
- Mutation
- Serpins