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Article

The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2004

Sakamaki Kazuhiro, Takagi Chiyo, Kominami Katsuya, Sakata Shin-ichi, Yaoita Yoshio, Kubota Hiroshi Y, Nozaki Masami, Yonehara Shin, Ueno Naoto

Abstract excerpt

FADD is an adaptor protein that transmits apoptotic signals from death receptors such as Fas to downstream initiator caspases in mammals. We have identified and characterized the Xenopus orthologue of mammalian FADD (xFADD). xFADD contains both a death effector domain (DED) and a death domain (DD) that are structurally homologous to those of mammalian FADD. We observed xFADD binding to Xenopus caspase-8 and...

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Identifiers

PMID: 15569156
DOI: 10.1111/j.1365-2443.2004.00802.x

Genes

FADD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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