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Article

Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice.

Cell death & disease - 10 Apr 2014

Ewald F, Annemann M, Pils M C, Plaza-Sirvent C, Neff F, Erck C, Reinhold D, Schmitz I

Abstract excerpt

Death receptor-mediated apoptosis is a key mechanism for the control of immune responses and dysregulation of this pathway may lead to autoimmunity. Cellular FLICE-inhibitory proteins (c-FLIPs) are known as inhibitors of death receptor-mediated apoptosis. The only short murine c-FLIP splice variant is c-FLIPRaji (c-FLIPR). To investigate the functional role of c-FLIPR in the immune system, we used the vavFLIPR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24722293
DOI: 10.1038/cddis.2014.138
PMCID: PMC5424115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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