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Article

A conserved signalling pathway for amoebozoan encystation that was co-opted for multicellular development.

Scientific reports - 16 Apr 2015

Kawabe Yoshinori, Schilde Christina, Du Qingyou, Schaap Pauline

Abstract excerpt

The evolution of multicellularity required novel mechanisms for intercellular communication, but their origin is unclear. Dictyostelium cells exchange signals to position specialized cell types in multicellular spore-bearing structures. These signals activate complex pathways that converge on activation of cAMP-dependent protein kinase (PKA). Genes controlling PKA were detected in the Dictyostelid unicellular...

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Identifiers

PMID: 25881075
DOI: 10.1038/srep09644
PMCID: PMC4399386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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