A role for cAMP-dependent protein kinase A in early Dictyostelium development.

doi:10.1101/gad.4.1.18

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A role for cAMP-dependent protein kinase A in early Dictyostelium development.

Genes & development - 1 Jan 1990

Firtel R A, Chapman A L

Abstract excerpt

In Dictyostelium, cAMP functions as an extracellular regulatory molecule that controls aggregation, expression of a number of classes of genes, and cellular differentiation by binding to cell-surface receptors that activate intracellular signal transduction pathways. To investigate possible roles for intracellular cAMP, we have overexpressed the wild-type mouse type-I regulatory subunit (RI) of cAMP-dependent...

Topics

Adenylyl Cyclases
Animals
Base Sequence
Binding Sites
Carrier Proteins
Cyclic AMP
Dictyostelium
Enzyme Activation
Gene Expression Regulation, Enzymologic
Genes, Fungal
Guanylate Cyclase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intracellular Signaling Peptides and Proteins

Mice

Molecular Sequence Data

Mutation

Phenotype

Protein Kinases

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 1968413
DOI: 10.1101/gad.4.1.18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1968413-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role for cAMP-dependent protein kinase A in early Dictyostelium development.PMID 1968413Read ↗

Multiple roles for cAMP-dependent protein kinase during Dictyostelium development.Semantic proximity Read ↗

Regulation of Dictyostelium early development genes in signal transduction mutants.Semantic proximity Read ↗

Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression in dictyostelium.Semantic proximity Read ↗

Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium.Semantic proximity Read ↗

cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development.Semantic proximity Read ↗

An adenylyl cyclase that functions during late development of Dictyostelium.Semantic proximity Read ↗

Molecular genetics of signal transduction in Dictyostelium.Semantic proximity Read ↗

Genome-wide expression analyses of gene regulation during early development of Dictyostelium discoideum.Semantic proximity Read ↗

A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures.Semantic proximity Read ↗

Direct biochemical measurements of signal relay during Dictyostelium development.Semantic proximity Read ↗

Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.Semantic proximity Read ↗

Loss of cAMP-specific phosphodiesterase rescues spore development in G protein mutant in dictyostelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.