Article
Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control.
Science (New York, N.Y.) - 15 May 1998
Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, Seth P K, Dotto G P
Abstract excerpt
The cyclin-dependent kinase inhibitor p21(Cip1/WAF1) has been implicated as an inducer of differentiation. However, although expression of p21 is increased in postmitotic cells immediately adjacent to the proliferative compartment, its expression is decreased in cells further along the differenti...
Topics
- Acetylcysteine
- Adenoviridae
- Animals
- Animals, Newborn
- Cell Cycle
- Cell Differentiation
- Cells, Cultured
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases
- Cyclins
- Enzyme Inhibitors
- Gene Expression Regulation
- Keratinocytes
- Leupeptins
- Membrane Proteins
- Mice
- Mutation
- Promoter Regions, Genetic