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Article

Immortalization of primary human keratinocytes by the helix–loop–helix protein, Id-1

17 Aug 1999

Abstract excerpt

Basic helix-loop-helix (bHLH) DNA-binding proteins have been demonstrated to regulate tissue-specific transcription within multiple cell lineages. The Id family of helix-loop-helix proteins does not possess a basic DNA-binding domain and functions as a negative regulator of bHLH proteins. Overexpression of Id proteins within a variety of cell types has been shown to inhibit their ability to differentiate under...

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Cancer-related Molecular Pathways
Cell death mechanisms and regulation
Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10449746
DOI: 10.1073/pnas.96.17.9637

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Click a neighbor to travelStep 1 · 12 closest

Immortalization of primary human keratinocytes by the helix–loop–helix protein, Id-1PMID 10449746Read ↗

Id-1 Delays Senescence but Does Not Immortalize KeratinocytesSemantic proximity Read ↗

ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesisSemantic proximity Read ↗

Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4aSemantic proximity Read ↗

Id proteins in epithelial cells.Semantic proximity Read ↗

Regulation of mammary epithelial cell phenotypes by the helix-loop-helix protein, Id-1.Semantic proximity Read ↗

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.Semantic proximity Read ↗

Id‐1 promotes proliferation of p53‐deficient esophageal cancer cellsSemantic proximity Read ↗

Human keratinocytes are efficiently immortalized by a Rho kinase inhibitorSemantic proximity Read ↗

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanismSemantic proximity Read ↗

Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism.Semantic proximity Read ↗

Regulation of Cellular Senescence and p16 Expression by Id1 and E47 Proteins in Human Diploid FibroblastSemantic proximity Read ↗

Role of Id family proteins in growth controlSemantic proximity Read ↗

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