Article

Benzo[a]pyrene induces keratinocyte senescence and p21-dependent differentiation

2026-05-12

Abstract excerpt

In this study, we demonstrate that Benzo[a]pyrene (B[a]P) induces keratinocyte senescence and p21 Cip1 -dependent keratinocyte differentiation. Atmospheric and environmental pollution are known to induce senescence and promote terminal differentiation in human primary keratinocytes, thus driving skin aging. However, much is still unknown about the underlying molecular mechanisms. We observed that B[a]P, a common...

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Literature Corpus work: 4c011803-61d5-5800-ac9f-e21c6142d72e
DOI: 10.64898/2026.05.08.723713

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