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Article

RB regulates transcription of the p21/WAF1/CIP1 gene.

Oncogene - 22 Feb 2001

Decesse J T, Medjkane S, Datto M B, Crémisi C E

Abstract excerpt

We have previously shown that RB plays an important role in the maintenance of the epithelial phenotype. p21 is also involved in several terminal differentiation systems including keratinocytes. We report here that p21 is an RB target gene in epithelial cells, but not in fibroblasts where RB is u...

Read the complete abstract on PubMed

Topics

Animals
Cell Cycle
Cell Differentiation
Cells, Cultured
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA-Binding Proteins
Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epithelial Cells

Feedback

Fibroblasts

Mice

Models, Genetic

Phenotype

Point Mutation

Promoter Regions, Genetic

Protein Binding

Response Elements

Source

Identifiers

PMID: 11314031
DOI: 10.1038/sj.onc.1204169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11314031-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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RB regulates transcription of the p21/WAF1/CIP1 gene.PMID 11314031Read ↗

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p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.Semantic proximity Read ↗

The Role of Sp1 Family Members, the Proximal GC-Rich Motifs, and the Upstream Enhancer Region in the Regulation of the Human Cell Cycle Inhibitor p21 <sup>WAF</sup> <sup>-</sup> <sup>1/Cip1</sup> Gene PromoterSemantic proximity Read ↗

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Regulation of cell proliferation by induction of p21/WAF1 in rat bladder carcinoma cells using the Cre--loxP system.Semantic proximity Read ↗

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c-Jun Transactivates the Promoter of the Human p21 Gene by Acting as a Superactivator of the Ubiquitous Transcription Factor Sp1Semantic proximity Read ↗

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