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Article

RB regulates transcription of the p21/WAF1/CIP1 gene.

Oncogene - 22 Feb 2001

Decesse J T, Medjkane S, Datto M B, Crémisi C E

Abstract excerpt

We have previously shown that RB plays an important role in the maintenance of the epithelial phenotype. p21 is also involved in several terminal differentiation systems including keratinocytes. We report here that p21 is an RB target gene in epithelial cells, but not in fibroblasts where RB is unable to transactivate p21 transcriptional expression. In epithelial cells, when RB family factors were inactivated by...

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Identifiers

PMID: 11314031
DOI: 10.1038/sj.onc.1204169

Genes

GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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RB regulates transcription of the p21/WAF1/CIP1 gene.PMID 11314031Read ↗

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The Role of Sp1 Family Members, the Proximal GC-Rich Motifs, and the Upstream Enhancer Region in the Regulation of the Human Cell Cycle Inhibitor p21 <sup>WAF</sup> <sup>-</sup> <sup>1/Cip1</sup> Gene PromoterSemantic proximity Read ↗

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