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Article

Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16<sup>Ink4a</sup>

6 Dec 2014

Abstract excerpt

The cyclin-dependent kinase (Cdk) inhibitor p16(Ink4a) (p16) is a canonical mediator of cellular senescence and accumulates in aging tissues, where it constrains proliferation of some progenitor cells. However, whether p16 induction in tissues is sufficient to inhibit cell proliferation, mediate senescence, and/or impose aging features has remained unclear. To address these issues, we generated transgenic mice...

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PMID: 25481981
DOI: 10.1111/acel.12279

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