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Article

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.

Biochimica et biophysica acta - 16 Dec 2002

Wang Zeping, Bhattacharya Nandini, Mixter Philip F, Wei Wenyi, Sedivy John, Magnuson Nancy S

Abstract excerpt

The serine/threonine kinase, Pim-1, appears to be involved in regulating proliferation, differentiation and cell survival of lymphoid and myeloid cells. In this study, we have found that amino acid residues 140-147 (RKRRQTSM) at the C-terminal end of p21(Cip1/WAF1), a cyclin-dependent kinase (CDK) inhibitor, constitute an ideal phosphorylation consensus sequence for Pim-1. We demonstrate that Pim-1 efficiently...

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Identifiers

PMID: 12431783
DOI: 10.1016/s0167-4889(02)00347-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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