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Article

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.

Oncogene - 11 Sept 2014

Saiz-Ladera Cristina, Lara María Fernanda, Garín Marina, Ruiz Sergio, Santos Mirentxu, Lorz Corina, García-Escudero Ramón, Martínez-Fernández Mónica, Bravo Ana, Fernández-Capetillo Oscar, Segrelles Carmen, Paramio Jesús M

Abstract excerpt

The retinoblastoma gene product (pRb) controls proliferation and differentiation processes in stratified epithelia. Importantly, and in contrast to other tissues, Rb deficiency does not lead to spontaneous skin tumor formation. As the cyclin-dependent kinase inhibitor p21 regulates proliferation and differentiation in the absence of pRb, we analyzed the consequences of deleting p21 in pRb-ablated stratified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24121270
DOI: 10.1038/onc.2013.417
PMCID: PMC4913869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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