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p300 Alters Keratinocyte Cell Growth and Differentiation through Regulation of p21Waf1/CIP1

12 Jan 2010

Abstract excerpt

BACKGROUND: p300 functions as a transcriptional co-activator to regulate many cellular responses such as cell growth, transformation, development and differentiation. It has been shown to affect the transcriptional activity of p53 which regulates p21(Waf1/CIP1) expression, however, the role of p300 in differentiation remains unclear. METHODOLOGY AND PRINCIPAL FINDINGS: Knockdown of p300 protein with short hairpin...

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PMID: 20084294
DOI: 10.1371/journal.pone.0008369

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