Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation.

doi:10.1126/science.273.5273.359

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Article

Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation.

Science (New York, N.Y.) - 19 Jul 1996

Wang J, Walsh K

Abstract excerpt

Proliferating murine C2C12 myoblasts can undergo either terminal differentiation or programmed cell death under conditions of mitogen deprivation. Unlike myoblasts, differentiated myotubes were resistant to apoptosis. During myogenesis the appearance of the apoptosis-resistant phenotype was corre...

Topics

Animals
Apoptosis
Carrier Proteins
Cell Differentiation
Cell Line
Culture Media
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinases
Cyclins
Enzyme Inhibitors
Mice
Muscles
Myogenin
Phenotype
Transfection

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