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Article

Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation.

Science (New York, N.Y.) - 19 Jul 1996

Wang J, Walsh K

Abstract excerpt

Proliferating murine C2C12 myoblasts can undergo either terminal differentiation or programmed cell death under conditions of mitogen deprivation. Unlike myoblasts, differentiated myotubes were resistant to apoptosis. During myogenesis the appearance of the apoptosis-resistant phenotype was correlated with the induction of the cyclin-dependent kinase (Cdk) inhibitor p21(CIP1) but not with the appearance of...

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Identifiers

PMID: 8662523
DOI: 10.1126/science.273.5273.359
PMCID: PMC3641673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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