Article
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
Genes & development - 15 Jan 1999
Zhang P, Wong C, Liu D, Finegold M, Harper J W, Elledge S J
Abstract excerpt
Cell-cycle arrest is thought to be required for differentiation of muscle cells. However, the molecules controlling cell-cycle exit and the differentiation step(s) dependent on cell-cycle arrest are poorly understood. Here we show that two Cdk inhibitors, p21(CIP1) and p57(KIP2), redundantly cont...
Topics
- Animals
- Apoptosis
- Bone Development
- Cell Cycle
- Cell Differentiation
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinase Inhibitor p57
- Cyclins
- DNA
- Female
- Gene Expression Regulation, Developmental
- Lung
- Male
- Mice
- Mice, Transgenic
- Morphogenesis
- Muscle, Skeletal
- Mutation