Article
Yeast prt1 mutations alter heat-shock gene expression through transcript fragmentation.
The EMBO journal - 1 Aug 1993
Barnes C A, Singer R A, Johnston G C
Abstract excerpt
The inhibition of translation initiation by modification or mutation of initiation factors can lead to disproportionate effects on gene expression. Here we report disproportionate decreases in gene expression in cells with mutated Prt1 activity. The PRT1 gene product of the budding yeast Saccharomyces cerevisiae is necessary for translation initiation and is thought to be a component of initiation factor 3. At a...
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