Article
The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.
Genes & development - 1 Dec 1991
Leeds P, Peltz S W, Jacobson A, Culbertson M R
Abstract excerpt
mRNA decay rates often increase when translation is terminated prematurely due to a frameshift or nonsense mutation. We have identified a yeast gene, UPF1, that codes for a trans-acting factor whose function is necessary for enhanced turnover of mRNAs containing a premature stop codon. In the absence of UPF1 function, frameshift or nonsense mutations in the HIS4 or LEU2 genes that normally cause rapid mRNA decay...
Topics
- Base Sequence
- Cloning, Molecular
- Codon
- DNA
- Fungal Proteins
- Histidine
- Molecular Sequence Data
- Mutation
- Peptide Chain Termination, Translational
- Plasmids
- Protein Biosynthesis