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Article

Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.

RNA (New York, N.Y.) - 1 Apr 2004

Keeling Kim M, Lanier Jessica, Du Ming, Salas-Marco Joe, Gao Lin, Kaenjak-Angeletti Anisa, Bedwell David M

Abstract excerpt

The Nonsense-Mediated mRNA Decay (NMD) pathway mediates the rapid degradation of mRNAs that contain premature stop mutations in eukaryotic organisms. It was recently shown that mutations in three yeast genes that encode proteins involved in the NMD process, UPF1, UPF2, and UPF3, also reduce the efficiency of translation termination. In the current study, we compared the efficiency of translation termination in a...

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Source

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Identifiers

PMID: 15037778
DOI: 10.1261/rna.5147804
PMCID: PMC1262634

Genes

UPF1
UPF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.PMID 15037778Read ↗

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ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.Semantic proximity Read ↗

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