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Article

An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA.

The EMBO journal - 1 Nov 1999

Welch E M, Jacobson A

Abstract excerpt

Yeast cells containing a temperature-sensitive mutation in the PRT1 gene were found to selectively stabilize mRNAs harboring early nonsense codons. The similarities between the mRNA decay phenotypes of prt1-1 cells and those lacking the nonsense-mediated mRNA decay (NMD) factor Upf1p led us to determine whether both types of mutations cause the accumulation of the same mRNAs. Differential display analysis and...

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Identifiers

PMID: 10545123
DOI: 10.1093/emboj/18.21.6134
PMCID: PMC1171677

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