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Article

Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH).

Genes & development - 1 May 1998

Herman C, Thévenet D, Bouloc P, Walker G C, D'Ari R

Abstract excerpt

Proteins with short nonpolar carboxyl termini are unstable in Escherichia coli. This proteolytic pathway is used to dispose of polypeptides synthesized from truncated mRNA molecules. Such proteins are tagged with an 11-amino-acid nonpolar destabilizing tail via a mechanism involving the 10Sa (SsrA) stable RNA and then degraded. We show here that the ATP-dependent zinc protease HflB (FtsH) is involved in the...

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Identifiers

PMID: 9573051
DOI: 10.1101/gad.12.9.1348
PMCID: PMC316767

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Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH).PMID 9573051Read ↗

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