Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH).

doi:10.1101/gad.12.9.1348

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Article

Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH).

Genes & development - 1 May 1998

Herman C, Thévenet D, Bouloc P, Walker G C, D'Ari R

Abstract excerpt

Proteins with short nonpolar carboxyl termini are unstable in Escherichia coli. This proteolytic pathway is used to dispose of polypeptides synthesized from truncated mRNA molecules. Such proteins are tagged with an 11-amino-acid nonpolar destabilizing tail via a mechanism involving the 10Sa (Ssr...

Topics

ATP-Dependent Proteases
Adenosine Triphosphatases
Amino Acid Sequence
Bacterial Proteins
Base Sequence
Cytoplasm
DNA Primers
Endopeptidase Clp
Escherichia coli
Escherichia coli Proteins
Genetic Variation
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

RNA, Bacterial

Serine Endopeptidases

Substrate Specificity

Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 9573051
DOI: 10.1101/gad.12.9.1348
PMCID: PMC316767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9573051-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH).PMID 9573051Read ↗

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