Article
The C-terminal end of LpxC is required for degradation by the FtsH protease.
Molecular microbiology - 1 Feb 2006
Führer Frank, Langklotz Sina, Narberhaus Franz
Abstract excerpt
Lipopolysaccharide (LPS) biosynthesis is essential in Gram negative bacteria. LpxC, the key enzyme in LPS formation, catalyses the limiting reaction and controls the ratio between LPS and phospholipids. As overproduction of LPS is toxic, the cellular amount of LpxC must be regulated carefully. The membrane-bound protease FtsH controls the level of LpxC via proteolysis making FtsH the only essential protease of...
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