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Article

Evolution of the ssrA degradation tag in Mycoplasma: specificity switch to a different protease.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2008

Gur Eyal, Sauer Robert T

Abstract excerpt

Stalled ribosomes in bacteria are rescued by the tmRNA system. In this process, the nascent polypeptide is modified by the addition of a short C-terminal sequence called the ssrA tag, which is encoded by tmRNA and allows normal termination and release of ribosomal subunits. In most bacteria, ssrA-tagged proteins are degraded by the AAA+ protease, ClpXP. However, in bacterial species of the genus Mycoplasma, genes...

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Identifiers

PMID: 18852454
DOI: 10.1073/pnas.0808802105
PMCID: PMC2570983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evolution of the ssrA degradation tag in Mycoplasma: specificity switch to a different protease.PMID 18852454Read ↗

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