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Article

SsrA-mediated tagging and proteolysis of LacI and its role in the regulation of lac operon.

The EMBO journal - 17 Jul 2000

Abo T, Inada T, Ogawa K, Aiba H

Abstract excerpt

SsrA RNA of Escherichia coli, also known as 10Sa RNA or tmRNA, acts both as tRNA and mRNA when ribosomes are paused at the 3' end of an mRNA lacking a stop codon. This process, referred to as trans-translation, leads to the addition of a short peptide tag to the C-terminus of the incomplete nascent polypeptide. The tagged polypeptide is then degraded by C-terminal-specific proteases. Here, we focused on...

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Share to RNA, Bacterial
Share to Cyclic AMP Receptor Protein
Share to Isopropyl Thiogalactoside

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lac Operon

Share to Lac Repressors

Share to Operator Regions, Genetic

Share to Protein Processing, Post-Translational

Share to RNA, Transfer

Source

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Identifiers

PMID: 10899129
DOI: 10.1093/emboj/19.14.3762
PMCID: PMC313975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SsrA-mediated tagging and proteolysis of LacI and its role in the regulation of lac operon.PMID 10899129Read ↗

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