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Article

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system.

Genes & development - 1 May 1998

Gottesman S, Roche E, Zhou Y, Sauer R T

Abstract excerpt

Interruption of translation in Escherichia coli can lead to the addition of an 11-residue carboxy-terminal peptide tail to the nascent chain. This modification is mediated by SsrA RNA (also called 10Sa RNA and tmRNA) and marks the tagged polypeptide for proteolysis. Degradation in vivo of lambda repressor amino-terminal domain variants bearing this carboxy-terminal SsrA peptide tag is shown here to depend on the...

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Identifiers

PMID: 9573050
DOI: 10.1101/gad.12.9.1338
PMCID: PMC316764

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The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system.PMID 9573050Read ↗

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