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Article

Degradation of SsrA-tagged proteins in streptococci.

Microbiology (Reading, England) - 1 Apr 2015

Tao Liang, Biswas Indranil

Abstract excerpt

In prokaryotes, a conserved small RNA molecule, called tmRNA, rescues ribosomes from proteins that are abnormally truncated due to the presence of rare codons or degraded mRNA. During the rescue process, a peptide tag (SsrA) encoded by tmRNA is cotranslationally added to the truncated polypeptides, thereby targeting these proteins for proteolytic degradation. In Escherichia coli, ClpXP and ClpAP proteases...

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Identifiers

PMID: 25645948
DOI: 10.1099/mic.0.000048
PMCID: PMC4857447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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