Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA.

Abstract excerpt

Escherichia coli FtsH (HflB) is a membrane-bound and ATP-dependent zinc-metalloproteinase, which forms a complex with a pair of periplasmically exposed membrane proteins, HflK and HflC. It is the protease that degrades uncomplexed forms of the SecY subunit of protein translocase. Here, we charact...

Topics

• ATP-Dependent Proteases
• Amino Acid Sequence
• Bacterial Proteins
• Base Sequence
• Endopeptidases
• Escherichia coli
• Escherichia coli Proteins
• Membrane Proteins
• Molecular Sequence Data
• Mutation
• Phenotype
• SEC Translocation Channels
• Substrate Specificity