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Article

A trapping approach reveals novel substrates and physiological functions of the essential protease FtsH in Escherichia coli.

The Journal of biological chemistry - 14 Dec 2012

Westphal Kai, Langklotz Sina, Thomanek Nikolas, Narberhaus Franz

Abstract excerpt

Proteolysis is a universal strategy to rapidly adjust the amount of regulatory and metabolic proteins to cellular demand. FtsH is the only membrane-anchored and essential ATP-dependent protease in Escherichia coli. Among the known functions of FtsH are the control of the heat shock response by proteolysis of the transcription factor RpoH (σ(32)) and its essential role in lipopolysaccharide biosynthesis by...

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Identifiers

PMID: 23091052
DOI: 10.1074/jbc.M112.388470
PMCID: PMC3522291

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A trapping approach reveals novel substrates and physiological functions of the essential protease FtsH in Escherichia coli.PMID 23091052Read ↗

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