Article
Carboxy-terminal determinants of intracellular protein degradation.
Genes & development - 1 Feb 1990
Parsell D A, Silber K R, Sauer R T
Abstract excerpt
Using the amino-terminal domain of lambda repressor as a model system, we show that residues in an unstructured region at the extreme carboxyl terminus of the protein are important for determining its proteolytic susceptibility in Escherichia coli. Nonpolar amino acids are destabilizing when plac...
Topics
- Amino Acid Sequence
- Chromosome Deletion
- DNA-Binding Proteins
- Escherichia coli
- Hot Temperature
- Intracellular Fluid
- Molecular Sequence Data
- Mutation
- Peptide Hydrolases
- Plasmids
- Protein Denaturation
- Repressor Proteins
- Structure-Activity Relationship
- Transcription Factors
- Viral Proteins
- Viral Regulatory and Accessory Proteins