Article
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.
Nature - 6 Mar 1997
Tondravi M M, McKercher S R, Anderson K, Erdmann J M, Quiroz M, Maki R, Teitelbaum S L
Abstract excerpt
Osteoclasts are multinucleated cells and the principal resorptive cells of bone. Although osteoclasts are of myeloid origin, the role of haematopoietic transcription factors in osteoclastogenesis has not been explored. Here we show that messenger RNA for the myeloid- and B-cell-specific transcription factor PU.1 progressively increases as marrow macrophages assume the osteoclast phenotype in vitro. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.