Article
VDJ genes in VHa2 allotype-suppressed rabbits. Limited germline VH gene usage and accumulation of somatic mutations in D regions.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1991
Short J A, Sethupathi P, Zhai S K, Knight K L
Abstract excerpt
In this study we investigate the molecular genetic basis for VHa- Ig. Knowing that the expression of VHa allotype Ig is suppressed by neonatal injection of rabbits with anti-VHa allotype antibody, and that the decreased level of VHa allotype Ig, VHa+, in the suppressed rabbits is compensated for...
Topics
- Amino Acid Sequence
- Animals
- Antibody Diversity
- Base Sequence
- DNA
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Immunoglobulin Allotypes
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Polymerase Chain Reaction
- Rabbits