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Article

Restricted V<sub>H</sub> Gene Usage and Generation of Antibody Diversity in Rabbit

1 Apr 1992

Abstract excerpt

The presence of VHa allotypic specificities on nearly all rabbit Ig molecules has perplexed immunologists for many years. How could these allotypic specificities be inherited as if controlled by alleles if the germline has hundreds of VHa allotype-encoding genes and if most of these genes are used in VDJ gene rearrangements. I review recent data indicating that the allelic inheritance of the VHa allotypes can be...

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Identifiers

PMID: 1590997
DOI: 10.1146/annurev.iy.10.040192.003113

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restricted V<sub>H</sub> Gene Usage and Generation of Antibody Diversity in RabbitPMID 1590997Read ↗

Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity.Semantic proximity Read ↗

Preferrential rearrangement in normal rabbits of the 3' VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences.Semantic proximity Read ↗

Limited number of immunoglobulin VH regions expressed in the mutant rabbit "Alicia".Semantic proximity Read ↗

VDJ genes in VHa2 allotype-suppressed rabbits. Limited germline VH gene usage and accumulation of somatic mutations in D regions.Semantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits.Semantic proximity Read ↗

Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids.Semantic proximity Read ↗

Generation of the primary antibody repertoire in rabbits: expression of a diverse set of Igk-V genes may compensate for limited combinatorial diversity at the heavy chain locusSemantic proximity Read ↗

VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression.Semantic proximity Read ↗

B lymphocyte selection and age-related changes in VH gene usage in mutant Alicia rabbits.Semantic proximity Read ↗

VH mutant rabbits lacking the VH1a2 gene develop a2+ B cells in the appendix by gene conversion-like alteration of a rearranged VH4 gene.Semantic proximity Read ↗

B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix.Semantic proximity Read ↗

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