Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity.

Cell - 23 Mar 1990

Knight K L, Becker R S

Abstract excerpt

Rabbits are unique in that their immunoglobulin VH regions bear allotypic markers encoded by allelic genes. The presence of these markers on most serum immunoglobulins is difficult to explain, as the germline contains several hundred VH genes. We cloned VH genes from normal rabbits of the VHa allotypes a1, a2, and a3 and from a mutant a2 rabbit, Alicia, which expresses almost no a2 allotype. The D-proximal VH...

Topics

Alleles
Amino Acid Sequence
Animals
Antibody Diversity
Base Sequence
Cloning, Molecular
Cosmids
Gene Library
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Homozygote
Immunoglobulin Allotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Molecular Sequence Data

Rabbits

Restriction Mapping

Source

Identifiers

PMID: 2317867
DOI: 10.1016/0092-8674(90)90344-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2317867-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity.PMID 2317867Read ↗

Restricted V<sub>H</sub> Gene Usage and Generation of Antibody Diversity in RabbitSemantic proximity Read ↗

Preferrential rearrangement in normal rabbits of the 3' VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences.Semantic proximity Read ↗

Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits.Semantic proximity Read ↗

VDJ genes in VHa2 allotype-suppressed rabbits. Limited germline VH gene usage and accumulation of somatic mutations in D regions.Semantic proximity Read ↗

Limited number of immunoglobulin VH regions expressed in the mutant rabbit "Alicia".Semantic proximity Read ↗

VH mutant rabbits lacking the VH1a2 gene develop a2+ B cells in the appendix by gene conversion-like alteration of a rearranged VH4 gene.Semantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression.Semantic proximity Read ↗

Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region.Semantic proximity Read ↗

B lymphocyte selection and age-related changes in VH gene usage in mutant Alicia rabbits.Semantic proximity Read ↗

Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids.Semantic proximity Read ↗

Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.