Article
Limited number of immunoglobulin VH regions expressed in the mutant rabbit "Alicia".
European journal of immunology - 1 Jun 1990
DiPietro L A, Short J A, Zhai S K, Kelus A S, Meier D, Knight K L
Abstract excerpt
A unique feature of rabbit Ig is the presence of VH region allotypic specificities. In normal rabbits, more than 80% of circulating immunoglobulin molecules bear the VHa allotypic specificities, al, a2 or a3; the remaining 10% to 20% of immunoglobulin molecules lack VHa allotypic specificities and are designated VHa-. A mutant rabbit designated Alicia, in contrast, has predominantly serum immunoglobulin molecules...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation
- Poly A
- RNA, Messenger