Article
Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Allegrucci M, Newman B A, Young-Cooper G O, Alexander C B, Meier D, Kelus A S, Mage R G
Abstract excerpt
Rabbits of the Alicia strain have a mutation (ali) that segregates with the immunoglobulin heavy-chain (lgh) locus and has a cis effect upon the expression of heavy-chain variable-region (VH) genes encoding the a2 allotype. In heterozygous a1/ali or a3/ali rabbits, serum immunoglobulins are almost entirely the products of the normal a1 or a3 allele and only traces of a2 immunoglobulin are detectable. Adult...
Topics
- Animals
- Chromosome Deletion
- Crosses, Genetic
- DNA Probes
- Female
- Genes, Immunoglobulin
- Haplotypes
- Homozygote
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region