VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression.

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Article

VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1993

Chen H T, Alexander C B, Young-Cooper G O, Mage R G

Abstract excerpt

Rabbits of the Alicia strain, derived from rabbits expressing the VHa2 allotype, have a mutation in the H chain locus that has a cis effect upon the expression of VHa2 and VHa- genes. A small deletion at the most J-proximal (3') end of the VH locus leads to low expression of all the genes on the...

Topics

Amino Acid Sequence
Animals
Antibody Diversity
Base Sequence
Gene Expression Regulation
Genes, Immunoglobulin
Immunoglobulin Allotypes
Immunoglobulin Heavy Chains
Immunoglobulin Joining Region
Immunoglobulin Variable Region
Molecular Sequence Data
Mutation
Rabbits

Source

Open in PubMed

Identifiers

PMID: 8454855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8454855-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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