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Article

B lymphocyte selection and age-related changes in VH gene usage in mutant Alicia rabbits.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1999

Zhu X, Boonthum A, Zhai S K, Knight K L

Abstract excerpt

Young Alicia rabbits use VHa-negative genes, VHx and VHy, in most VDJ genes, and their serum Ig is VHa negative. However, as Alicia rabbits age, VHa2 allotype Ig is produced at high levels. We investigated which VH gene segments are used in the VDJ genes of a2 Ig-secreting hybridomas and of a2 Ig+ B cells from adult Alicia rabbits. We found that 21 of the 25 VDJ genes used the a2-encoding genes, VH4 or VH7; the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10477601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

B lymphocyte selection and age-related changes in VH gene usage in mutant Alicia rabbits.PMID 10477601Read ↗

VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression.Semantic proximity Read ↗

Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits.Semantic proximity Read ↗

VDJ genes in VHa2 allotype-suppressed rabbits. Limited germline VH gene usage and accumulation of somatic mutations in D regions.Semantic proximity Read ↗

VH mutant rabbits lacking the VH1a2 gene develop a2+ B cells in the appendix by gene conversion-like alteration of a rearranged VH4 gene.Semantic proximity Read ↗

Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits.Semantic proximity Read ↗

Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region.Semantic proximity Read ↗

Preferrential rearrangement in normal rabbits of the 3' VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences.Semantic proximity Read ↗

Limited number of immunoglobulin VH regions expressed in the mutant rabbit "Alicia".Semantic proximity Read ↗

Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity.Semantic proximity Read ↗

Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection.Semantic proximity Read ↗

Restricted V<sub>H</sub> Gene Usage and Generation of Antibody Diversity in RabbitSemantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

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