Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoglobulin as a vehicle for foreign antigenic peptides immunogenic to T cells.

Molecular immunology - 1 Jan 2000

Lunde E, Bogen B, Sandlie I

Abstract excerpt

Antibody (Ab) molecules may serve as targeting vehicles for delivery of foreign antigenic peptides to antigen presenting cells (APC). An attractive strategy is to substitute segments between beta-strands of immunoglobulin (Ig) constant (C)-region domains with antigenic peptides. For this to work, the mutant Ab must maintain its conformation so that it can be secreted from transfected cells. Furthermore, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to CHO Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cricetinae

Share to Genes, Immunoglobulin

Share to Molecular Sequence Data

Share to Mutation

Share to Transfection

Source

Identifiers

PMID: 9566764
DOI: 10.1016/s0161-5890(97)00143-0

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoglobulin as a vehicle for foreign antigenic peptides immunogenic to T cells.PMID 9566764Read ↗

Antibodies designed as effective cancer vaccinesSemantic proximity Read ↗

T cell recognition of somatically-generated Ab diversity.Semantic proximity Read ↗

Structural definition by antibody engineering of an idiotypic determinant.Semantic proximity Read ↗

The CLIP-substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cells.Semantic proximity Read ↗

Expression of monovalent fragments derived from a human IgM autoantibody in E. coli. The input of the somatically mutated CDR1/CDR2 and of the CDR3 into antigen binding specificity.Semantic proximity Read ↗

Mutation of a single conserved residue in VH complementarity-determining region 2 results in a severe Ig secretion defect.Semantic proximity Read ↗

A single amino acid mutation in CDR3 of the 3-14-9 L chain abolished expression of the IDA 10-defined idiotope and antigen binding.Semantic proximity Read ↗

Removal of Amphipathic Epitopes from Genetically Engineered Antibodies: Production of Modified Immunoglobulins with Reduced ImmunogenicitySemantic proximity Read ↗

Coordination of immunoglobulin chain folding and immunoglobulin chain assembly is essential for the formation of functional IgG.Semantic proximity Read ↗

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.Semantic proximity Read ↗

CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.Semantic proximity Read ↗

Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.